Lead: Utrecht University December 2025

D2.3 Systematic review report and updates V2

The second iteration completes and updates the Knowledge Warehouse. A second Screenathon screened a further 5,842 records and added 221 publications to the 266 already included, covering roughly 4,668 individual studies across 11 disease areas including oncology, cardiovascular disease, neurology and ophthalmology. The analysis is candid about what the evidence base looks like: a geographical bias towards Western countries, uneven coverage between conditions — breast cancer well documented, atrial fibrillation barely — and PROMs far better represented than PREMs or patient preference information.

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